Our bispecific platform is a technology that holds great promise. In the past, this has been referred to as DVD platform. In fact, this platform is capable of producing a wide range of different bispecific formats and DVD is just a small portion. These bispecific formats have a broad range of protein binding and biologic characteristics.
In oncology, we view our bispecific platform as a path to new biology rather than simply to combination therapy. For example, we are studying the uses of our bispecifics to enhance the performance of antibody-drug conjugates (ADCs). In preclinical systems, we can show that a bispecific that binds to two portions of the same molecular target is taken up in the cancer cells better than a traditional ADC. This could deliver a greater toxin load, thereby enhancing efficacy.
Similarly, a bispecific that binds to two molecular targets from the same cancer cell can be used to increase tumor specificity, allowing us to prosecute targets that had some degree of expression in normal tissue. With our bispecific platform, we are able to create a wide range of protein constructs, ultimately leading to new biology with different mechanisms of action.